We note that a recent meta-analysis of prospective cohort studies observes consistency of evidence regarding a lower dementia risk associated with the use of renin-angiotensin system inhibitors in patients with high blood pressure.55 Lifestyle habits that contribute to the prevention of cardio-cerebral vascular disease may reduce the risk of dementia and reduce the risk of CKD progression.7,8,56. This evidence concerns the gene REN and chronic kidney disease.