Even in human cancer cell lines where MYXV is permissive and can complete the full virus replication cycle and make progeny virions (for example, A549 lung epithelial carcinoma and 786-0 renal carcinoma cells), DHX9 knockdown further increased progeny virus titer when infected at a low multiplicity of infection (MOI) (i.e., facilitated spread of progeny virus). Here, DHX9 is linked to infection.