Methylation test for the two differentially methylated regions (DMRs) ICR1 and ICR2 regions at chromosome 11p15, the GRB10-PEG1/MEST loci at chromosome 7 and the DLK1-MEG3 locus at chromosome 14q32 were negative excluding main causes of Silver-Russell syndrome. This evidence concerns the gene MEG3 and Silver-Russell syndrome.