It is concluded that l-CIT supplementation for eight weeks in the patients with T2D could increase serum levels of CIT and reduce the serum concentrations of fasting blood glucose, HbA1c without any statistically significant effect on insulin sensitivity indices, as well as serum MCP-1, TLR-4, and IL-6 concentrations. This evidence concerns the gene CCL2 and type 2 diabetes mellitus.