In fact, serum insulin and HOMA-IR did not change significantly over the intervention in both groups (data are not shown).The group analysis at the end of study for the changes in the serum levels of CIT, glucose response, and meta-inflammatory biomarkers indicated the significant differences in the serum levels of CIT as well as fasting blood glucose, insulin, HOMA-IR, and HbA1c after adjusting for the baseline values, diabetes duration, and changes in energy intake and BMI (p = 0.006, p = 0.032, p = 0.025, p = 0.037, p = 0.001, respectively). This evidence concerns the gene INS and diabetes mellitus.