INS and diabetes mellitus: Lower levels of NO may reduce glucose transport, resulting in the insulin resistance and diabetes [44].NO is involved in increasing insulin sensitivity in a number of ways, including by increasing the expression and translocation of glucose transporter type 4 (GLUT4) in the skeletal muscle of type 2 diabetic rats [45, 46], as well as by decreasing gluconeogenesis [47] and increasing Hepatic insulin sensitization (HISS) secretion [48].