Using our Methylation Outlier Detector algorithm, we identified 8 markers (cg01908954-SCG3, cg15085899-NCOR2, cg14781189-KCNH7, cg03242819-DOCK1, cg05491001-cg054, cg25567674-cg255 cg04640109-ZFPM2 and cg07950000-GRIK1) (Additional file 5: Table S1) that were highly methylated (β value greater than 0.20) in all 48 DLBCL samples, and had a β value less than 0.15 in all 656 of the GBM and LGG samples. This evidence concerns the gene NCOR2 and diffuse large B-cell lymphoma.