We found that 5 of the 8 markers (cg054, SCG3, KCNH7, ZFPM2 and GRIK1) showed distinctly higher levels of methylation in PCNSL, ALL and CLL in comparison with the hematopoietic stem cells, B-cell precursors and B-cells. This evidence concerns the gene SCG3 and acute lymphoblastic leukemia.