Al-Hendy et al. [15], who researched the role of 1.25 (OH) 2D3 in the expression of sex steroid receptors in leiomyoma cells, realized that the deregulation of steroid hormones and their receptors could be a primary factor of myoma growth since 1.25 (OH) 2D3 VDR expression but acts as an antiestrogenic agent in these cells. This evidence concerns the gene VDR and leiomyoma.