Previous studies have shown that the upregulation or downregulation of m6A methylation regulator is associated with the occurrence of many different tumors, and the same m6A methylation regulator may have different functions in different tumors, such as acute myeloid leukemia, glioblastoma, non-small cell lung cancer, liver cancer, and breast cancer [29–34]. This evidence concerns the gene METTL3 and liver cancer.