Despite the utility of Martin’s formula, the pathophysiology of FCHL with a concurrent insulin resistant state, increased lipolysis and variable expression of triglyceride-variants in this condition offers variable increases in triglyceride concentration, diminishing the utility of this formula as LDL-C is modified by treatment in the setting of hypertriglyceridemia and mixed dyslipidaemia. This evidence concerns the gene INS and hypertriglyceridemia.