Next, the wild-type targeting sites in LncRNA SNHG15 (Wt-SNHG15) and 3′ UTR of c-Myc (Wt-Myc) were mutated, and they were named as Mut-SNHG15 and Mut-Myc, respectively, the dual-luciferase reporter gene system assay results indicated that the relative luciferase activity was decreased by miR-451 mimic, and was increased by miR-451 inhibitor in BC cells co-transfecting with Wt-SNHG15 (Fig. 2b, c) and Wt-Myc (Fig. 2e, f), instead of their corresponding mutant counterparts, suggesting that we had validated the binding sites among LncRNA SNHG15, miR-451 and c-Myc. Here, MYC is linked to breast cancer.