Given the fact that miRNAs targeted 3′UTRs of cancer associated genes, by screening the existed publications in the online Pubmed database (https://pubmed.ncbi.nlm.nih.gov/), we noticed that c-Myc was proved to be the downstream target of miR-451 [27, 28], and researchers found that miR-451 targeted c-Myc to promote the development of bladder cancer [27] and lung adenocarcinoma [28], but the role of miR-451/c-Myc axis in regulating BC progression is still unknown. This evidence concerns the gene MYC and urinary bladder carcinoma.