We have shown that isoDGR-coated gold nanospheres can be exploited as a versatile platform for single- or multicytokine delivery to cells of the tumor vasculature and that extremely low doses of isoDGR-coated nanoparticles functionalized with TNF or with TNF + IL12 can induce synergistic effects with doxorubicin. This evidence concerns the gene TNF and neoplasm.