The aim of the present study was to assess clinically through measuring: pocket probing depth (PPD), clinical attachment level (CAL), GI and BOP and biochemically through measuring the MMP-8 levels in GCF the effect of intrapocket application of TTO (Melaleuca alternifolia) gel adjunctive to SRP on the management of stage 2 (moderate) periodontitis and to correlate the GCF levels of MMP-8 with clinical response. Here, MMP8 is linked to periodontitis.