Some researchers suggest that many pathways, such as target-of-rapamycin complex 1 (Torc1), AMP-activated protein kinase (AMPK), transcription factor EB (TFEB), peroxisome proliferator activated receptor (PPAR), P53, nuclear erythroid 2-related factor 2 (Nrf2), c-jun Nterminal kinase (JNK), toll-like receptors (TLRs), myeloid differentiation primary-response protein 88 (Myd88), and nuclear factor κB (NF-κB) signaling pathways, might be related to fatty liver caused by high-fat/carbohydrate or over-nutrition diet [11–17]. This evidence concerns the gene NFE2L2 and fatty liver disease.