NUDT15 and Decreased total leukocyte count: More specifically, start 30% to 80% of the normal dose (for example, 0.6–2.4 mg/kg/day) for NUDT15 intermediate metabolizer, and drastically reduced normal daily doses (reduced daily dose by 10-fold) or an alternative immunosuppressant therapy for NUDT15 poor metabolizer, including switching to 6-MP or thioguanine, desensitization, subdivide the total ideal thiopurine dose into 2 smaller daily doses.[12] Furthermore, Wang et al[20] have showed that the combined use of corticosteroids may decrease the risk of developing AZA-induced leukopenia.