CD30+ primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare ALK-negative T-cell neoplasm with an annual incidence of 10 per million persons.[1] Patients with this malignancy usually present with indolent solitary or localized nodules with or without ulcerative lesions. This evidence concerns the gene TNFRSF8 and anaplastic large cell lymphoma.