OTX2 and hypopituitarism: No OTX2 mutations were found in 264 Brazilian patients with hypopituitarism without eye abnormalities, with the exception of patient 9, consistent with previous studies such as that reported by Dateki  et al., where no OTX2 mutations were identified in 66 patients with hypopituitarism and no ocular abnormalities, as opposed to 5/28 being described in patients with ocular malformations (35).