APC and adenoma: Ectopic activation of beta‐catenin, either directly or in Apc mutant intestinal cells, is sufficient to induce expanded hypertrophic proliferation along the crypt‐villus axis or formation of adenomas (Korinek et al,1997; Morin et al,1997; Harada et al,1999; Sansom et al,2004; Andreu et al,2005).