LATS1 and neoplasm: Furthermore, Lats1/2 dKO organoids grow normally and express Sox9 (Appendix Fig S3), while expression of transgenic nlsYAP5SA does not impair growth of Apcfl/fl p53fl/fl knockout organoids in vitro (Appendix Fig S4) or formation of tumours after subcutaneous implantation into nude mice (Appendix Fig S5).