APC and neoplasm: This model proposes a post‐translational mechanism for Wnt‐dependent regulation of YAP subcellular localisation and stability, a notion that has been challenged by the observation that acute deletion of Apc in the intestine is not always sufficient to cause nuclear localisation of YAP, indicating that signals other than Wnt must drive YAP nuclear localisation during regeneration and tumour formation (Gregorieff et al,2015; Gregorieff & Wrana, 2017).