YAP1 and neoplasm: Very recently, two groups reported that YAP activation can directly inhibit Wnt signalling in the intestine (Cheung et al,2020; Li et al,2020), with one report claiming that YAP therefore functions as a tumour suppressor, rather than an oncogene, in colorectal cancer (Cheung et al,2020), building on their previous work (Barry et al,2013), but in conflict with other reports of an oncogenic role for YAP in the intestine (Cai et al,2015; Gregorieff et al,2015).