However, YAP was dispensable for proliferative hypertrophy upon acute Apcflox/flox homozygous deletion throughout the intestine (Gregorieff et al,2015; Taniguchi et al,2015; Taniguchi et al,2017), suggesting that hypertrophic growth is simply an expansion of the normal Wnt‐dependent, YAP‐independent, homeostatic proliferation programme, while tumour formation may require additional input from other signals that induce YAP nuclear translocation. This evidence concerns the gene YAP1 and neoplasm.