CTNNB1 and neoplasm: One key target gene of beta‐catenin/TCF is Myc, encoding a transcription factor expressed in a crypt‐villus gradient that is required to promote cell proliferation during normal intestinal homeostasis and tumour formation (He et al,1998; Muncan et al,2006; Sansom et al,2007; Finch et al,2009).