Very recently, Li et al (2020) and Cheung et al (2020) reported that activation of YAP directly inhibits Wnt signalling in the intestinal epithelium, with one of these reports claiming that YAP therefore functions as a “tumour suppressor” in colorectal cancer (Cheung et al,2020), in line with previous work from the same group (Barry et al,2013). The gene discussed is YAP1; the disease is neoplasm.