Subsequently, the PI3K/AKT/GSK3β pathway has been pointed out the crucial roles in acute myocardial infarction to inhibit cardiomyocyte apoptosis by increasing expression of antiapoptosis protein, B‐cell lymphoma‐2 (Bcl-2), and reducing the expressions of proapoptosis proteins including Bax and cleaved-caspase 3 [40]. This evidence concerns the gene GSK3B and acute myocardial infarction.