CD274 and neoplasm: Companion biomarkers for pembrolizumab monotherapy include high PD-L1 expression on the membrane of tumor cells alone or in combination of the membrane expression on immune cells by immunohistochemistry for selected cancer types, including NSCLC (2015), gastric cancer (2017), cervical (2018), urothelial cancer (2018), esophageal squamous cell carcinoma (2019) and head or neck squamous cell cancer (2019) [35–37].