Passive immunotherapy in these two individuals did not result in clearance of PSP-tau inclusions, corroborated by digital image analysis of the percent area occupied by PHF1 immunoreactivity from midbrain sections comparing these two immunized PSP cases (1.03% ± 0.12) with 9 unimmunized PSP cases which included the unimmunized sibling (1.06% ± 0.17; Supplemental Fig. 1). The gene discussed is PHF1; the disease is supranuclear palsy, progressive, 1.