We found upregulation of p53 signaling pathway-related genes, such as Ccng1, Trp53inp1 and Cdkn1a, in full locus Cables2d gastrulas that accompanied with decreased expression of Rps21. The transcription factor p53 is well-known to function in DNA damage responses and tumor suppression in cancer (Vogelstein et al., 2000; Zilfou and Lowe, 2009). This evidence concerns the gene RPS21 and neoplasm.