We hypothesize that obese individuals with BD in a euthymic phase present WM microstructural damage related to BMI, as a possible consequence of an unbalanced allostatic and pro-inflammatory profile.4 Therefore, this is a proof-of-concept study that aims to: 1) investigate associations between BMI and FA in individuals with BD during euthymia in comparison with a control group of healthy individuals (CTR) and 2) test whether any possible association is mediated by inflammation measured by CRP. This evidence concerns the gene CRP and Behcet disease.