The authors discussed a possible inflammatory process, but no inflammatory markers were actually assayed.9 , 10 C-reactive protein (CRP) is a sensitive marker of peripheral inflammation that has been extensively reported in obesity.12 Also, it has already been associated with WM microstructural damage in severe mental illness,13 so it constitutes a promising candidate to test the hypothesis of inflammatory damage in obese bipolar patients. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.