CRP and Behcet disease: Accelerated aging of the WM, especially in limbic communication structures, could be the pathway underlying such microstructural damage associated with BMI in BD, but with uncertain etiology.7 Chronic inflammatory status is a good candidate for the neuroimmunological abnormalities that occur in severe psychiatric disorders8 and could mediate the deleterious effect of BMI in WM.9 , 10 In our study, higher BMI was indeed correlated with increased pro-inflammatory cytokines in our population measured by CRP, but this correlation was not seen in BD, only among CTR.