Participants with CKD and sarcopenia had a 33% higher relative hazard of mortality compared with CKD individuals without sarcopenia (HR 1.33; 95% CI: 1.07 to 1.66; P = 0.011), adjusted for age, sex, ethnicity, number of comorbidities, CRP, albumin, testosterone, Hb, and BMI; in the non‐CKD group, the corresponding HR was 1.37 (1.28 to 1.47; P < 0.001). The gene discussed is GSTM1; the disease is chronic kidney disease.