The central role of the DMN in AD (Brier et al., 2012; Buckner et al., 2005; Garces et al., 2014; Zhou et al., 2010) and its strong associations with amyloid (Buckner et al., 2005; Hedden et al., 2009; Sperling et al., 2009; Wang et al., 2013) and tau deposition (Cope et al., 2018; Jones et al., 2016; Wang et al., 2013) has been consistently documented. Here, MAPT is linked to Alzheimer disease.