DSG2 and cardiomyopathy: To further confirm the pathological relevance of desmoglein-2 deficiency, we introduced NHEJ-mediated frameshift mutation into additional two iPSCs generated from the father of the patient (I-1, Fig. 1A) carrying heterozygous R119X mutation [named Paternal-iPSC (Pat-iPSC)] and from the other cardiomyopathy patient in which the pathogenic variant was not identified in DSG2 [named cardiomyopathy-iPSC (Cm-iPSC)].