The rs34536443 C allelealso decreased IL-23 and IL-12 induced-p-STAT3 levels in a murine model of MS (Gorman et al., 2019).Accordingly, PBMCs of patients with MS carrying the C allele of this SNP also showedreduced IFNβ induced-p-STAT2 levels compared to patients with the G allele (Couturier et al., 2011). The gene discussed is STAT3; the disease is myeloid sarcoma.