TYK2 and rheumatoid arthritis: The authors showed an association betweenthe TYK2 rs2304256 and rs34536443 SNPs and MS, RA, SLE, CD, and UC.Lee and Bae (2016) performed ameta-analysis of 12 studies regarding the association of 7 TYK2SNPs with SLE and RA, showing the rs2304256 and rs1270356 minor alleles wereassociated with protection against these rheumatic diseases.