Thence, we speculated that GSEC, NONHSAT160878.1 might be involved in the progression of pediatric sepsis by regulating MAPK signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, IL-17 signaling pathway, phagosome pathway, metabolic pathways, insulin signaling pathway, complement and coagulation cascades and chemokine signaling pathway to have potential function on pediatric sepsis. This evidence concerns the gene TNF and Sepsis.