For example, the star lncRNA HOTAIR has been reported to be a driver of hepatocarcinogenesis via miR-218 [28]; however, it respectively bound to androgen receptor [29], miR-149-5p [30], miR-206 [31], miR-601 [32], and miR-1277-5p [33] in renal cell carcinoma, non-small cell lung cancer, ovarian cancer and breast cancer, exerting its pro-tumor role. This evidence concerns the gene AR and breast cancer.