As previously reported, NEDD4‐2 bound to ion channels (I Na and I Kr), resulted in ubiquitination and degradation, and thus its isoform NEDD4‐2 C2‐induced electrophysiological impairment and triggered both cardiac conduction alterations and pro‐arrhythmic changes in post‐acute myocardial infarctions.30 This evidence concerns the gene NEDD4L and acute myocardial infarction.