XK and acute myocardial infarction: As previously reported, NEDD4‐2 bound to ion channels (I Na and I Kr), resulted in ubiquitination and degradation, and thus its isoform NEDD4‐2 C2‐induced electrophysiological impairment and triggered both cardiac conduction alterations and pro‐arrhythmic changes in post‐acute myocardial infarctions.30