AAV‐miR‐454 led to a decrease in the rate of apoptosis, reduced expression of Bax and cleaved caspase‐3 and increased Bcl‐2 expression in the myocardial tissues of rats rendered with HF, whereas all of which could be reversed by treatment with H‐89 (Figure 8F, G, Figure S2D). Here, BAX is linked to hydrops fetalis.