Since extracellular HMGB1 binds to several receptors, including receptor for advanced glycation end products (RAGE) and Toll‐like receptor 4 (TLR4), to promote inflammation and tumour growth, we explored whether RAGE or TLR4 mediated HMGB1‐induced ERK1/2 and Drp1 activation and PASMCs proliferation/migration. Here, TLR4 is linked to neoplasm.