Analysis of TME in all four cases showed comparable characteristics Overall, in all four cases, analysis of the macrophages encircling the tumour areas by the use of mIHC showed a prevalence of M1 macrophages, defined as CD68+/CD163–/c‐Maf– cells, accounting for 80–95% of the total macrophages, whereas M2 macrophages (CD68+/CD163+/c‐Maf+) were scarce (5–20%) (Figure 4A,B; Table 2). This evidence concerns the gene CD68 and neoplasm.