Although GnRH is an effective hormonal treatment for EM, severe hypoestrogenic symptoms limit long‐term compliance.31, 32 GnRH agonists are second‐line hormonal therapies that exert strong action on the GnRH receptor, leading to an initial short stimulation and subsequent suppression of gonadotropin secretion. This evidence concerns the gene GNRH1 and erythema multiforme.