Melatonin also inhibits angiogenesis via VEGF and oxidative stress via regulating radical scavenging activity and amplifies apoptotic activity via CASP3 mediated pathway in vivo and in vitro in EM.63, 142, 143 Melatonin has no adverse effects on reproductive functions, instead, it can improve ovarian functions, and thus has potential to treat EM‐related infertility.296, 297 High‐dose intravenous treatment of pain and sepsis with melatonin showed no adverse effects.298. Here, VEGFA is linked to erythema multiforme.