GnRH agonists, such as leuprolide acetate or the preclinical nonhormonal drug propofol, increased the levels of proapoptotic proteins, as well as decreased the levels of antiapoptotic proteins and promitogenic cytokines.52, 100 Melatonin is highly effective in amplification of apoptotic activity via regulating MMP‐3 signal, was able to regress EM at either early or late stage. Here, MMP3 is linked to erythema multiforme.