For CM-induced pY-STAT3, patients whose AML cells had ∆MFI ≤ 1.76 (n = 33) had a 5-year EFS of 36.4 ± 16.7% (Fig. 3b), compared to the 80 patients whose AML cells responded above this threshold (57.2 ± 11.4%, p = 0.051). Here, STAT3 is linked to acute myeloid leukemia.