Out of a total of 105 POLE carriers and 27 POLD1 carriers, of which 43 POLE carriers and 17 POLD1 carriers were female, the following had sufficient information to be included in the analysis of cumulative risk of (1) CRC: POLE N = 103 POLD1 N = 27 (2) EC POLE N = 43, POLD1 N = 13, (3) colorectal adenomas POLE N = 87, POLD1 N = 25 (4) any cancer POLE N = 94 POLD1 N = 27. This evidence concerns the gene POLE and colorectal carcinoma.