Individuals without CRAs were either young (aged 24 and 18 respectively), or carried a relatively rare probably pathogenic variant and presented with an extra-colonic tumour (POLE p.Tyr458Phe, POLD1 p. Asp316Gly, POLD1 p. Asp316Asn, POLD1 p. Leu474Pro). This evidence concerns the gene POLE and colonic neoplasm.