While this could indicate that too frequent exposure to mitazalimab results in depletion of DC via antibody-dependent cellular cytotoxicity and thus a reduced anti-tumor efficacy, there are no reports of preclinical or clinical studies that suggest that anti-CD40 antibodies mediate depletion of DC, despite that most CD40 agonists used in preclinical models engage Fcγ receptors. The gene discussed is CD40; the disease is neoplasm.