In the current work, we observed a slight, non-significant decrease in the expression levels of p21CIP1, and H3K9Me3 (although both were positively expressed in most samples) and a significant decline in the expression of Lamin B1 in patients who received NAC and that, based on staining for all three markers, senescence-like phenotype was identified within advanced breast cancers in response to NAC. This evidence concerns the gene CDKN1A and breast carcinoma.