However, in order to assess senescence induction in breast tumor samples based on the expression levels of the three markers, we considered samples that are only positive for p21CIP1, positive for H3K9Me3 and negative for Lamin B1 are most likely to be positive for a senescence-like phenotype post-NAC in consistence with the premise of utilizing multiple senescence-associated markers when evaluating senescence in vivo [27]. Here, CDKN1A is linked to breast neoplasm.