For Brugada syndrome cases, in particular, we describe that carrying 2 Hap1 copies in the enhancer-containing haplotype block is, potentially, the most common risk genotype (Hap1/1) in individuals of non-Finnish European ancestry, while carrying 1 Hap2 copy and 1 Hap3 copy (Hap2/3) would be the most common protective genetic feature. This evidence concerns the gene NFYB and Brugada syndrome.