Hap1 is substantially more abundant in Brugada syndrome cases than controls—initially counterintuitive, as Hap1 harbors the major allele in each rs1–7 position (Fisher’s exact test: p = 6.86e−14, 1KG-NFE; p = 9.41e−14, Wellderly-NFE; and p = 5.63e−13, GTEx-NFE; Figure 3D; Data S1, Table S5). This evidence concerns the gene HAP1 and Brugada syndrome.