CTCF and Brugada syndrome: ,31,32,34,41 For this reason, we also added to our annotations the regions containing the 2 lead SNVs that were previously associated with Brugada syndrome (rs10428132 and the isolated rs11708996), which do not apparently overlap with DHS, H3K4me3, or CTCF binding (Figures 1B and S1; NGS-based genotyping).