Neutrophil adaptation to the CF airway microenvironment features profound changes at the metabolic and functional levels, including increased numbers of polyribosomes, increased glycolytic activity, activation of the mTOR pathway, active release of primary granules, immune modulation, and decreased bacterial killing.17, 18, 19, 20 Our findings here demonstrate that this adaptation is driven by active transcription and translation and highlight the plasticity of neutrophils at the target organ. Here, MTOR is linked to cystic fibrosis.