MTOR and cystic fibrosis: ,20 The latter is reflected by an increased expression of nutrient transporters, enhanced glycolytic capacity, increased number of polyribosomes, and sustained activation of the mechanistic target of rapamycin (mTOR) anabolic pathway, a master regulator of cellular metabolism and nucleotide synthesis.21, 22, 23 Despite this sustained activation, CF airway neutrophils are unable to contain bacteria that progressively colonize patients’ lungs and worsen their outcomes.