In grade II MR1 high glioma, GO pathways, such as “positive regulation of toll-like receptor signaling, inflammatory cell apoptotic process, positive regulation of tumor necrosis factor biosynthetic process, and toll-like receptor 3 signaling pathways,” and KEGG pathways, such as “antigen processing and presentation, and systemic lupus erythematosus” were dysregulated. Here, TLR3 is linked to central nervous system cancer.