Overexpression of the EMT-associated marker WIP1 (wild-type p53-induced protein1) promotes cell migration and invasion in metastatic medulloblastoma patients and 2D cell migration models.31,32 To validate the 3D-BME model of medulloblastoma metastasis, we assessed whether expression of WIP1 increased in metastatic cell lines grown in 3D-BME and if the cells’ aggregation phenotype could be blocked by inhibiting WIP1. This evidence concerns the gene PPM1D and medulloblastoma.