A study in the USA shows Community-acquired pneumonia to be the leading cause of death in IBD patients. Literature declared the patients with IBD to be the most vulnerable to develop pneumonia, particularly those on corticosteroid and anti-TNF agent [23]. Cryptogenic Organizing pneumonia (COP), also called bronchiolitis obliterans with organizing pneumonia (BOOP), was found to be the most common non-infectious IBD-related parenchymal disease. The gene discussed is TNF; the disease is inflammatory bowel disease.