EGFR and gastric cancer: Importantly, ST6GAL1 knockout (K.O.)ErbB2-addicted GC cells displayed a reduced ErbB2 degradation rate, and enhanced sensitivity to trastuzumab-induced cytotoxicity, supported by a decreased ability to sustain ErbB2 and epidermal growth factor receptor (EGFR) intracytoplasmic phosphorylation, and increased stabilization of ErbB dimeric compositions at the cell membrane.