The identification of several oncogenic cell surface receptors as molecular targets of ST6Gal1, which is frequently overexpressed in the majority of solid human tumors, has uncovered the active role played by α2,6NeuAc motifs in supporting malignant cell pluripotency, invasive and metastatic capacities, and ability to evade apoptotic pathways and immune-mediated anti-tumor responses [10–14, 30, 31]. Here, CD177 is linked to neoplasm.