TP53 and colorectal carcinoma: Of note, we detected a lower frequency of TP53 mutation in BRCA-muc and PAAD-muc, a higher frequency of KRAS mutation in CRC-muc and LUAD-muc and a higher frequency of methylation silencing of TCF7 in CRC-muc and BRCA-muc and TCF7L2 and CDKN1B in BRCA-muc, although these observations did not reach statistical significance after correcting for multiple testing (Fig. 2c).