ROC curve analysis showed that the composite probability score combining MMP9, FARSB, PRDX2, CA-1, and PCSK9 could differentiate BD-II from controls with an AUC of 0.89 (P < 0.001, 95% CI = 0.86–0.93) (Fig. 1a). Here, FARSB is linked to Behcet disease.