JEB is caused by mutations either in LAMA3, LAMB3, or LAMC2 (which, together, encode laminin 332, also known as laminin 5), ITGA6 and ITGB4 (encoding α6β4 integrins), or COL17A1 (encoding collagen XVII)36. This evidence concerns the gene ITGA6 and junctional epidermolysis bullosa.