JEB is caused by mutations either in LAMA3, LAMB3, or LAMC2 (which, together, encode laminin 332, also known as laminin 5), ITGA6 and ITGB4 (encoding α6β4 integrins), or COL17A1 (encoding collagen XVII)36. The gene discussed is LAMC2; the disease is junctional epidermolysis bullosa.