Moreover, hsa_circ_0006401 peptides decreased the mRNA and protein level of the host gene col6a3 and TGFβ1 expression, the knockdown of hsa_circ_0006401 peptide also led to accelerated decay of the col6a3 mRNA, suggesting hsa_circ_0006401 peptides may promote proliferation and metastasis of CRC by protecting col6a3 mRNA from degradation. Here, COL6A3 is linked to colorectal carcinoma.