An analysis of published transcriptomic data in the Stemformatics database25,26 further supports significant upregulation of PANX1 in macrophages subjected to various immunological challenges27–30 (e.g., Toll-like receptor (TLR) agonist, proinflammatory cytokine, tuberculosis, Supplementary Fig. S9a). The gene discussed is PANX1; the disease is tuberculosis.