PSME3 and neoplasm: Furthermore, while immunohistochemistry (IHC) analysis revealed cytoplasmic localization of β-catenin in normal tissues, IHC detected obvious nuclear localization of β-catenin in tumor tissues from both Uhrf1+/+/ApcMin/+ and Uhrf1ki/ki/ApcMin/+ mice (Supplementary Fig. 4A, B).