Moreover, the Uhrf1-TTD-KI mice had a significantly reduced number of large-size tumors (tumors with diameter L ≥ 3 mm and 3 > L ≥ 2 mm) than wild-type mice (Fig. 2D–E), although the difference in tumor lesions with a size smaller than 2 mm is less significant. This evidence concerns the gene UHRF1 and neoplasm.