Similar to the results from AOM/DSS-induced tumor model, measurement of 5mC levels in normal tissues from Apc+/+ background and tumors from Apcmin/+ background revealed a substantial reduction of DNA methylation in tumors, and the DNA hypomethylation phenotype is more drastic in tumors from the Uhrf1ki/ki/ApcMin/+ mice (Fig. 3H). This evidence concerns the gene PSME3 and neoplasm.