While microglial cells seem to be represented in a greater proportion in AD brains, scRNA-Seq studies have found microglial populations to be a small fraction of total cell types regardless of disease status [31].TREM2 also binds to amyloid directly, with nanomolar affinity, and activates microglial clearance of amyloid deposition [67, 70]. The gene discussed is TREM2; the disease is Alzheimer disease.