The remaining 8 genes comprising 6 distinct non-overlapping 1 MB genomic regions and are significantly associated to AD after JCP and SMR with FDR corrected p values are as follows: APOC1 (JCP = 2.22e−22, SMR = 3.41e−4), EED (JCP = 3.373e−5, SMR = 2.50e−4), CD2AP (JCP = 2.96e−5, SMR = 2.66e−4), CEACAM19 (JCP = 3.27e−5, SMR = 1.00e−2), CLPTM1 (JCP = 4.04e−3, SMR = 2.58e−3), MTCH2 (JCP = 0.011, SMR = 3.32e−6), TREM2 (JCP = 0.021, SMR = 2.64e−3), and KNOP1(JCP = 0.039, SMR = 2.50e−4). This evidence concerns the gene APOC1 and Alzheimer disease.