Consistent with the APOC1 role in lipid transport and immune activation, our expanded cell process enrichments specifically identified phagocytosis and activation of immune response (Fig. 3b), supporting a shared role between APOE and APOC1 as the biological contributor to enhanced AD risk and making the disentanglement of each gene’s unique AD risk contribution that much more difficult. The gene discussed is APOE; the disease is Alzheimer disease.