CD8A and neoplasm: Notwithstanding and whether considering the total area of tumor microenvironment, a high percentage of activated CD8 + Granzyme B+ T lymphocytes among total CD8+ T cells was associated with a significantly prolonged survival (median OS: 135.6 months in the High group vs. 26.2 months in the Low group; HR 0.24, 95% CI 0.06–0.89, p = 0.022; Fig. 4a).