These included genes with key-roles in the pathogenesis of idiopathic and/or monogenic PD: SNCA, MAPT, APP, PRKN and PARK7. Interestingly, the significantly hyperacetylated peak in SNCA was in an enhancer region of the gene previously shown to be affected by both genetic variation [63] and drug exposure associated with PD [64] (Fig. 5a). Here, APP is linked to Parkinson disease.